13 patients with advanced breast cancer (received first line chemotherapy) were eligible. Each patient was treated with FEM chemotherapy, on days 1 and 7 in combination with WBH, antihormonal therapy and local electro magnetic hyperthermia (13,56 MHz) .
Chemotherapy:
750 mg 5-FU day 1,2,3,7,14
30 mg Epirubicin day 1,7
10 mg Mitomycin C day 1,2
Results: we obtained in 30,7% Complete Remission (CR), 38,5% Partial Remission (PR), 23,2% No Change (NC). We compared our results with results of effective classic regimens in the treatment of metastatic breast cancer ( J. Smith and J. Powels, 1993 Oncology), statistic not significant.

13 patients with advanced ovarian cancer after surgical procedure and previous multiple chemotherapes (until 8 regimens) and 36 patients with advanced breast cancer after extensive pretreatment were eligible.
During the WBH a core temperature of 41.5º - 42ºC was attained in the rectum. The head was cooled once a temperature of 40ºC had been reached. We combined the WBH with 300-400mg/dl artificial hyperglycemia (HG). The plateau temperature was held over a period on average of 90±30min, the HG on average 240±30min. WBH was repeated at the beginning of each new chemotherapy cycle. WBH were administered between 1 and 5 times, on average 3. After reaching the maximum temperature plateau, each patient received chemotherapy; this was dependant upon response of previous therapies.

Many biological attributes of tumours can deteriorate homogeneity distribution of heat during hyperthermia. Temperature expansion and temperature elevation are directly dependant on regional blood flow and microcirculation and varying tissue thermal tolerance characteristics. (We attempted to determine the connection between the microcirculation status of osteogenic sarcomas and the morphological changes and devitalisation in the tumour tissues (pathomorphosis or posttreatment histology) after a complex neoadjuvant treatment with chemotherapy and irradiation in combination with local electro magnetic hyperthermia. 62 patients with histology verfied osteosarcoma (35 men, 27 women), average age 21 (9 to 53), were chosen for this study. In 72,6% of these cases the tumour was localized in the bones forming the knee joints. All patients received a complex neoadjuvant treatment (60 minutes local regional hyperthermia (42-45°C), and monochemotherapy i.v. or i.a. with rubomycin 30-50 mg/m² 6 infusions, adriamycin or cisplatin single dose of 30 mg/m² for 3 days or once 90mg/m² before hyperthermic procedure; subsequently enforced distant gamma-therapy). Surgery was done after the treatment. 20 patients underwent a primary operation were included in a control group. Every resected tumour was histologicaly investigated in detail for assessment of therapeutic induced alterations - pathomorphosis. Minimal devitalisation of the tumour parenchyma complied with the 2. Grade of therapeutic pathomorphosis, subtotaled with the 3. Grade, total devitalisation (100% necrosis of the tumour parenchyma) corresponded with grade 4 of therapeutic pathomorphosis. Using a light microscope combined with a semiautomatic picture analysis PC-system "Integral 2 MT" we evaluated the functionality status of microcirculation on histological cuts and measured the total surface (m m2) of 50 vessels in every tumour. The investigated vessels of control tumours displaced from 2,85 to 73,4% of damage of the microcirculation, in median 21,69 %. A relative low amount of regional dose radio therapy (20-36 Gy) and chemotherapy with adriamycin and cisplatin using 5-6 applications of local hyperthermia induced distinct damage to tumour tissue: in 39,3% cases sub-total and in 35,7% total (devitalisation of tumour parenchyma). Thrombosis of magistral and middle vessels, obstruction of blood flow and stasis in microcirculation tree (collapse), damage of vessels intima and of endothelial cells, necrotic alterations of the vessels walls appeared predominantly in central areas of the tumours. Likewise exhibit peripheric tumour zones noticeable signs of microcirculation disturbance. In tumours with pathomorphosis grade 2 reach share of nonfunctional vessels from 10,6 till 61,7%, in median 29,7%. From 34,5 till 72,0% - in median 49,46% - of vessels in tumours with a third pathomorphosis grade were nonfunctional (stasis, thrombosis). In 10 cases with 4 pathomorphosis grade we registered the median of nonfunctional vessels in tumours of 56,05%. There is a direct correlation between the deterioration of the microcirculation in tumour tissue and it´s alteration throughout the thermoradiochemotherapy, the pathomorphosis grade is directly proportional with a number of nonfunctional vessels in the osteogenic sarcoma.